| Fatty liver, abdominal visceral fat, and cardiometabolic risk factors: the Jackson Heart Study. | |
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MedLine Citation:
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PMID: 21885852 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The goal of this study was to examine whether fatty liver and abdominal visceral adipose tissue (VAT) are jointly associated with cardiometabolic abnormalities. METHODS AND RESULTS: Black participants were from the Jackson Heart Study (n=2882, 65% women) who underwent computed tomography. Fatty liver was measured by liver attenuation in Hounsfield units (LA), and VAT was quantified volumetrically. Cross-sectional associations between LA, VAT, and cardiometabolic risk factors were assessed using linear and logistic regression, and their joint associations were further examined in 4 subgroups: high-LA/low-VAT (n=1704), low-LA/low-VAT (n=422), high-LA/high-VAT (n=436), and low-LA/high-VAT (n=320). Both LA and VAT were associated with most cardiometabolic traits (all P<0.0001), which persisted after additional adjustment for each other (LA, P<0.01-0.0001; VAT, P<0.0001). In bootstrap analyses, the regression coefficient of VAT was significantly greater than LA for triglycerides, high-density lipoprotein cholesterol, impaired glucose, and metabolic syndrome (P=0.009-0.0001). The interaction between LA and VAT was significant for high-density lipoprotein cholesterol (P=0.002), impaired glucose (P=0.003), and metabolic syndrome (P=0.04). Among 4 subgroups, participants with higher VAT and lower LA had higher prevalence of cardiometabolic traits than those with each condition alone. CONCLUSION: Both fatty liver and VAT are independent correlates of cardiometabolic risk, but the associations are stronger for VAT than for fatty liver. |
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Authors:
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Jiankang Liu; Caroline S Fox; DeMarc Hickson; Aurelian Bidulescu; J Jeffery Carr; Herman A Taylor |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 31 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-20 Completed Date: 2012-01-23 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 2715-22 Citation Subset: IM |
Affiliation:
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Jackson Heart Study, University of Mississippi Medical Center, Jackson State University, Jackson, MS 39213-4505, USA. jliu@umc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Continental Ancestry Group / ethnology Aged Aged, 80 and over Cardiovascular Diseases / epidemiology*, ethnology, physiopathology Cholesterol, HDL / blood Fatty Liver / blood, complications*, physiopathology Female Humans Intra-Abdominal Fat* / physiopathology Male Metabolic Diseases / epidemiology*, ethnology, physiopathology Metabolic Syndrome X / epidemiology*, ethnology, physiopathology Middle Aged Mississippi Regression Analysis Retrospective Studies Risk Factors Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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N01 HC095170/HC/NHLBI NIH HHS; N01 HC095171/HC/NHLBI NIH HHS; N01-C-95172//PHS HHS; N01-HC-95170/HC/NHLBI NIH HHS; N01-HC-95171/HC/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Triglycerides |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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