Document Detail


Fatty Acids Impair Endothelium-Dependent Vasorelaxation: A Link Between Obesity and Arterial Stiffness in Very Old Zucker Rats.
MedLine Citation:
PMID:  22389459     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
To analyze age-related interactions between obesity, its associated metabolic disorders, and macrocirculation, we studied large artery stiffness and fatty acid responsiveness in lean and obese Zucker rats, aged 25 (adult) and 80 weeks (very old). Systolic arterial pressure was higher in old obese than in old lean rats (178 ± 10 vs 134 ± 8 mmHg, respectively). Carotid elastic modulus-wall stress curves showed increased age-dependent arterial stiffening, which was greater in obese animals. Old obese exhibited endothelial dysfunction with increased systemic oxidative stress. Adult obese had elevated plasma free fatty acid levels (1,866 ± 177 vs 310 ± 34 μg/μL in lean animals). In old obese, linoleate and palmitate increased contractility to phenylephrine and reduced relaxation to acetylcholine. Thus, obesity at 25 weeks appears to trigger accelerated arterial aging observed at 80 weeks. The early increase in free fatty acids may be a key effector in the severe arterial stiffness of the aged obese Zucker model.
Authors:
Natacha Sloboda; Bruno Fève; Simon N Thornton; Rosine Nzietchueng; Véronique Regnault; Ginny Simon; Carlos Labat; Huguette Louis; Jean-Pierre Max; Adeline Muscat; Mary Osborne-Pellegrin; Patrick Lacolley; Athanase Benetos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-1
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  -     ISSN:  1758-535X     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Geriatrics, CHU Nancy, Hôpital Brabois, 54 510 Vandoeuvre-lès-Nancy, France. a.benetos@chu-nancy.fr.
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