| Fatty acid supply to the human fetus. | |
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MedLine Citation:
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PMID: 20438366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deposition of fat in the fetus increases exponentially with gestational age, reaching its maximal rate-around 7 g/day or 90% of energy deposition-at term. In late pregnancy, many women consuming contemporary Western diets may not be able to meet the fetal demand for n-3 long chain polyunsaturated fatty acids (LCPUFAs) from the diet alone. Numerous mechanisms have evolved to protect human offspring from extreme variation or deficiency in the maternal diet during pregnancy. Maternal adipose tissue is an important source of LCPUFA. Temporal changes in placental function are synchronized with maternal metabolic and physiological changes to ensure a continuous supply of n-3 and n-6 LCPUFA-enriched fat to the fetus. LCPUFA storage in fetal adipose tissue provides an important source of LCPUFA during the critical first months of postnatal life. An appreciation of these adaptations is important in any nutritional strategy designed to improve the availability of fatty acids to the fetus. |
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Authors:
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Paul Haggarty |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annual review of nutrition Volume: 30 ISSN: 1545-4312 ISO Abbreviation: Annu. Rev. Nutr. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8209988 Medline TA: Annu Rev Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 237-55 Citation Subset: IM |
Affiliation:
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Nutrition and Epigenetics Group, Rowett Institute of Nutrition & Health, University of Aberdeen, Aberdeen, AB21 9SB, Scotland, United Kingdom. p.haggarty@abdn.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Fatty Acids, Unsaturated / administration & dosage, deficiency, metabolism, physiology* Female Fetal Development / drug effects, physiology* Fetus / metabolism* Gestational Age Humans Maternal Nutritional Physiological Phenomena / physiology* Maternal-Fetal Exchange Nutritional Requirements Placenta / metabolism Pregnancy Prenatal Nutritional Physiological Phenomena / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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