Document Detail

The fatty acid profile of the erythrocyte membrane in initial-onset inflammatory bowel disease patients.
MedLine Citation:
PMID:  23306839     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: The sudden change in the dietary habits of the Japanese population towards a European/American-style diet since the 1960s is thought to be responsible for the recent increase in the incidence of inflammatory bowel disease (IBD) in Japan. Dietary fatty acid intake influences the fatty acid profiles of vital cell membranes, which might be a source of inflammatory mediators.
METHODS: We investigated the fatty acid composition of the erythrocyte membrane in 90 healthy Japanese and 43 initial-onset IBD patients (ulcerative colitis, UC: 25; Crohn's disease, CD: 18) who had not undergone any dietary intervention to examine the role fatty acids play in the onset of IBD.
RESULTS: The erythrocyte membrane n-3/n-6 ratio of the initial-onset IBD patients was 0.42 ± 0.13, which was not significantly different from that of the healthy Japanese subjects (0.41 ± 0.13). However, the CD patients displayed a significantly lower mean percentage weight (MPW) of linoleic acid (LA) than the healthy subjects (8.25 ± 1.75 vs. 9.90 ± 1.29; p < 0.001), while their MPW of arachidonic acid (AA) was significantly higher than those of the healthy subjects and UC patients (11.22 ± 2.18 vs. 9.76 ± 1.64, p < 0.01; vs. 9.58 ± 1.97, p < 0.01, respectively). The mean delta 6-desaturation index of the CD patients was significantly higher than that of the healthy subjects (1.61 ± 0.65 vs. 1.11 ± 0.26; p < 0.001).
CONCLUSIONS: The CD patients displayed significantly higher and lower MPW of AA and LA, respectively, than the healthy subjects, suggesting that delta 6-desaturase is hyperactivated in CD. The cell membrane fatty acid profile might be a therapeutic target in CD.
Kan Uchiyama; Shunichi Odahara; Makoto Nakamura; Shigeo Koido; Kiyohiko Katahira; Hiromi Shiraishi; Toshifumi Ohkusa; Kiyotaka Fujise; Hisao Tajiri
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Publication Detail:
Type:  Journal Article     Date:  2013-01-11
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  58     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-22     Completed Date:  2013-07-22     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1235-43     Citation Subset:  AIM; IM    
Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University Kashiwa Hospital, 163-1 Kashiwa-shita, Kashiwa, Chiba, 277-0004, Japan.
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MeSH Terms
Asian Continental Ancestry Group
Case-Control Studies
Erythrocyte Membrane / metabolism*
Fatty Acids / metabolism*
Inflammatory Bowel Diseases / metabolism*
Linoleoyl-CoA Desaturase / metabolism
Middle Aged
Phospholipids / metabolism*
Young Adult
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids; EC Desaturase
Comment In:
Dig Dis Sci. 2013 Jun;58(6):1806-7   [PMID:  23504329 ]

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