| Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease. | |
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MedLine Citation:
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PMID: 19904605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary omega3-polyunsaturated fatty acids are thought to influence the risk of Alzheimer's disease (AD), and supplemental docosahexaenoic acid (DHA; 22:6n-3) has been reported to reduce neurodegeneration in mouse models of AD. We have analysed the fatty acid composition of frontal, temporal and parietal neocortex in 58 normal and 114 AD brains. Significant reductions were found for stearic acid (18:0) in frontal and temporal cortex and arachidonic acid (20:4n-6) in temporal cortex in AD, and increases in oleic acid in frontal and temporal cortex (18:1n-9) and palmitic acid (16:0) in parietal cortex. DHA level varied more in AD than controls but the mean values were not significantly different. Fatty acid composition was not related to APOE genotype, age, gender or post-mortem delay. Further research is needed to distinguish between alterations that are secondary to AD and those that contribute to the disease process. |
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Authors:
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Thomas Fraser; Hannah Tayler; Seth Love |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-11 |
Journal Detail:
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Title: Neurochemical research Volume: 35 ISSN: 1573-6903 ISO Abbreviation: Neurochem. Res. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-10 Completed Date: 2010-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
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Languages: eng Pagination: 503-13 Citation Subset: IM |
Affiliation:
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Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol, Frenchay Hospital, Bristol, BS16 1LE, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aging / physiology Alzheimer Disease / metabolism* Apolipoproteins E / genetics Brain Chemistry / physiology* Docosahexaenoic Acids / metabolism Fatty Acids / metabolism* Female Gas Chromatography-Mass Spectrometry Genotype Humans Male Methylation Middle Aged Neocortex / metabolism* Postmortem Changes Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Fatty Acids; 25167-62-8/Docosahexaenoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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