Document Detail


Fatty Acid Composition of Epicardial and Subcutaneous Human Adipose Tissue.
MedLine Citation:
PMID:  19196081     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background: Epicardial adipose tissue has special properties that distinguish it from the more widely studied depots of adipose tissue. Objectives: We undertook this study to investigate regional differences between epicardial and subcutaneous adipose tissue fat composition, as well as associations between these measures and metabolic variables. Methods: Epicardial and subcutaneous peripheral adipose tissue were collected during coronary artery bypass grafting from 42 patients (ages 37-65) with coronary artery disease (CAD). The fatty acid composition of adipose tissue was determined by gas liquid chromatography (GLC). Results: The saturated fatty acids, including myristic acid (14:0), palmitic acid (16:0), and stearic acid (18:0), were higher, and the unsaturated fatty acids, including palmitoleic acid (16:1n-7), oleic acid (18:1n-9), linoleic acid (18:2n-6), and linolenic acid (18:3n-3), were lower than the subcutaneous adipose tissue. The presence of hypertension was positively correlated with the 16:1n-7 (r = 0.407, p = 0.032) and 18:1n-11(r = 0.370, p = 0.027), and negatively correlated with 18:1n-9 (r = -0.367, p = 0.036) and 18:2n-6 (r = -0.446, p = 0.006) contents of epicardial adipose tissue after adjustment for body mass index. Conclusions: Regional differences may be observed in fatty acid composition, suggesting a depot specific impact of stored fatty acids on adipocyte function and metabolism.
Authors:
Masoud Pezeshkian; Mohammad Noori; Hamideh Najjarpour-Jabbari; Aliakbar Abolfathi; Maryam Darabi; Masoud Darabi; Maghsod Shaaker; Ghader Shahmohammadi
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2009-1-18
Journal Detail:
Title:  Metabolic syndrome and related disorders     Volume:  -     ISSN:  1557-8518     ISO Abbreviation:  Metab Syndr Relat Disord     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150318     Medline TA:  Metab Syndr Relat Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiology, Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
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