Document Detail

Fatigue, sleep disturbance, disability, and indices of progression of HIV infection.
MedLine Citation:
PMID:  1554037     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The authors' objective was to test the hypothesis that fatigue affects the activities and employment of subjects with HIV infection and that indices of immunosuppression and inflammation may have statistical utility in predicting fatigue and sleep disturbance. METHOD: The authors prospectively asked 112 homosexual men (62 HIV-seropositive subjects and 50 HIV-seronegative comparison subjects) to complete a questionnaire on fatigue and sleep disturbance. In addition, hematocrit, WBC count, CD4+ cell number, lactate dehydrogenase, albumin, and total globulin were measured. RESULTS: For HIV-seropositive patients fatigue was significantly more of a problem and interfered more with important activities such as employment and driving than with seronegative comparison subjects. The HIV-infected patients were significantly more likely to be unemployed, to feel fatigued through more hours of the day, to sleep more, to nap more, and to have diminished midmorning alertness. The medical variables could be used to statistically predict fatigue, its interference with daily activities, and employment. CONCLUSIONS: Fatigue and sleep disturbances contribute to morbidity and disability in HIV-infected homosexual men, especially those in CDC stage IV (AIDS-related complex or AIDS). Correlation with measures of immunosuppression and inflammation and comparison between fatigued versus nonfatigued groups suggest the possibility of statistical prediction of fatigue by using these measures. Further study is needed to examine the possibility of eventual specific intervention to clinically treat HIV-related fatigue, sleepiness, and sleep disturbance.
D F Darko; J A McCutchan; D F Kripke; J C Gillin; S Golshan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  149     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-04-29     Completed Date:  1992-04-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  514-20     Citation Subset:  AIM; IM; X    
Department of Psychiatry, University of California, School of Medicine, San Diego.
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MeSH Terms
AIDS-Related Complex / diagnosis
Acquired Immunodeficiency Syndrome / diagnosis
Activities of Daily Living
Age Factors
Automobile Driving
Fatigue / diagnosis*
HIV Infections / diagnosis*
HIV Seropositivity / diagnosis
Prospective Studies
Severity of Illness Index
Sleep Disorders / diagnosis*
Grant Support

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