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Fatigue and plasma cytokine concentrations at rest and during exercise in patients with sarcoidosis.
MedLine Citation:
PMID:  21679351     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background:  Patients with sarcoidosis exhibit exercise intolerance-related fatigue and increased levels of circulating proinflammatory cytokines at rest. Exercise may result in increased plasma cytokine levels (PCLs) in healthy adults, but such a relationship has not been studied in sarcoidosis patients. Objectives:  To assess relationship of fatigue in sarcoidosis with PCLs at rest and with cardiopulmonary exercise testing (CPET). Methods:  We assessed lung function, CPET data, multidimensional fatigue inventory, plasma tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) concentrations before, immediately after, and 4-6 h following CPET in 22 sarcoidosis patients (13 receiving immunomodulatory drugs) and 22 controls. Results:  Patients exhibited greater fatigue, reduced cardiorespiratory function, higher Medical Research Council (MRC) scores and higher plasma TNF-α concentrations than controls at all times. Plasma IL-1β levels did not differ between cohorts. Patients exhibited a 28% increase (statistically not significant) in TNF-α level immediately post exercise. Plasma IL-β concentrations did not change among cohorts. Treated patients exhibited higher MRC and physical fatigue scores and lower breathing reserve, but no differences in cardiorespiratory function or PCLs compared to untreated patients. In treated patients, pre-exercise plasma IL-1β correlated with physical fatigue, reduced motivation and total fatigue; TNF-α levels only correlated with general fatigue score. Conclusion:  Treated sarcoidosis patients exhibit a relation between physical fatigue, reduced motivation and total fatigue and pre-exercise plasma IL-1β concentrations. Acute exercise does not increase PCLs. Whether the reduced MRC score and physical fatigue in treated patients is related to the therapy or to the underlying inflammatory process is difficult to determine. Please cite this paper as: Baydur A, Alavy B, Nawathe A, Liu S, Louie S and Sharma OP. Fatigue and plasma cytokine concentrations at rest and during exercise in patients with sarcoidosis. Clin Respir J 2011; 5: 156-164.
Authors:
Ahmet Baydur; Bahram Alavy; Amar Nawathe; Shanshan Liu; Stan Louie; Om Prakash Sharma
Publication Detail:
Type:  Journal Article     Date:  2010-06-30
Journal Detail:
Title:  The clinical respiratory journal     Volume:  5     ISSN:  1752-699X     ISO Abbreviation:  Clin Respir J     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101315570     Medline TA:  Clin Respir J     Country:  England    
Other Details:
Languages:  eng     Pagination:  156-64     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Affiliation:
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Division of General Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA School of Pharmacy, University of Southern California, Los Angeles, CA, USA.
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