Document Detail

Fatigue in multiple sclerosis: cross-sectional correlation with brain MRI findings in 71 patients.
MedLine Citation:
PMID:  10496289     Owner:  NLM     Status:  MEDLINE    
Fatigue is an unexplained but common and disabling symptom in MS. We assessed fatigue in 71 patients with MS and identified MS-fatigue (MSF) and MS-nonfatigue (MSNF) groups. Fatigue severity did not correlate with regional or global MRI plaque load or atrophy assessed by conventional sequences. No significant differences were noted in any MRI measures between MSF and MSNF groups. We suggest that brain MRI disease topography or severity does not explain fatigue in MS and that fatigue is likely due to mechanisms poorly characterized by conventional MRI.
R Bakshi; R S Miletich; K Henschel; Z A Shaikh; V Janardhan; M Wasay; L M Stengel; R Ekes; P R Kinkel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  53     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-15     Completed Date:  1999-11-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1151-3     Citation Subset:  AIM; IM    
Dent Neurologic Institute, Kaleida Health-Millard Fillmore Hospital, Department of Neurology, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, USA.
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MeSH Terms
Brain / pathology
Fatigue / etiology,  pathology*
Magnetic Resonance Imaging
Multiple Sclerosis / complications,  pathology*
Comment In:
Neurology. 2000 Apr 25;54(8):1709-10   [PMID:  10762529 ]

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