Document Detail

Fatigue in bronchiectasis.
MedLine Citation:
PMID:  22016379     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Fatigue is a complex, disabling symptom in non-CF bronchiectasis (nCF-Br). Fatigue can be formally measured using the validated fatigue impact scale (FIS). The relationship between fatigue and clinically important factors such as airflow obstruction, breathlessness or Pseudomonas aeruginosa infection in nCF-Br is unclear.
AIM: To measure the correlation between FIS scores and markers of disease severity in nCF-Br.
DESIGN: A prospective cohort study.
METHODS: Patients attending a specialist service were studied. Lung function (FEV(1)% predicted), Medical Research Council dyspnoea score (MRCD), sputum culture results and FIS were recorded. Patients were categorized according to sputum culture into three subgroups: Pseudomonas 'colonization', 'isolation' and neither.
RESULTS: One hundred and seventeen consecutive patients were included. Average FEV(1)% predicted was 64% (SD ±28%). Twelve (10%) patients had Pseudomonas aeruginosa isolation; 47 (40%) patients had P. aeruginosa colonization. Fatigue levels were similar in patients with and without colonization (median 38 versus 32, P = 0.155). Significant fatigue (FIS > 40) was similar in all three Pseudomonas subgroups (P = 0.31, chi-square). Fatigue correlated with MRCD score (r = 0.57, P < 0.001) and FEV(1)% predicted (r = -0.30, P = 0.001). FEV(1)% predicted was lower in patients who had ever isolated or been colonized with P. aeruginosa (P ≤ 0.001).
CONCLUSION: There are significant correlations between FIS score and MRCD score and FEV(1)% predicted in bronchiectasis. Pseudomonas aeruginosa infection appears to be associated with poorer lung function, and higher MRCD scores, yet there is no significant association between P. aeruginosa status and fatigue.
K L M Hester; J G Macfarlane; H Tedd; H Jary; P McAlinden; L Rostron; T Small; J L Newton; A De Soyza
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Publication Detail:
Type:  Journal Article     Date:  2011-10-20
Journal Detail:
Title:  QJM : monthly journal of the Association of Physicians     Volume:  105     ISSN:  1460-2393     ISO Abbreviation:  QJM     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-27     Completed Date:  2012-05-15     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9438285     Medline TA:  QJM     Country:  England    
Other Details:
Languages:  eng     Pagination:  235-40     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Biological Markers
Bronchiectasis / complications*
Cohort Studies
Fatigue / diagnosis,  etiology*
Middle Aged
Prospective Studies
Pseudomonas Infections / complications*
Pseudomonas aeruginosa*
Respiratory Function Tests
Sputum / microbiology
Young Adult
Grant Support
MR/J002712/1//Medical Research Council
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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