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Fatigue in Patients With Coronary Artery Disease: Association With Thyroid Axis Hormones and Cortisol.
MedLine Citation:
PMID:  23023678     Owner:  NLM     Status:  Publisher    
ObjectiveIn people with coronary artery disease, the association between endocrine measures and fatigue is not well understood. We evaluated possible associations of fatigue and exercise capacity with function of adrenal axis and thyroid axis.MethodsSixty-five men and 18 women aged 55 (9) years attending a rehabilitation program were examined using the Multidimensional Fatigue Inventory, Dutch Exertion Fatigue Scale, and the Hospital Anxiety and Depression Scale. Exercise capacity was measured using a bicycle ergometer procedure. Serum concentrations of free triiodothyronine (T(3)), free thyroxine (T(4)), morning cortisol, afternoon cortisol, and change in cortisol concentrations (ΔCortisol) were measured.ResultsIn univariate regression analysis, lower free T(4) concentrations were associated with general and exertion fatigue, lower free T(3) concentrations were associated with general and physical fatigue, and lower ΔCortisol was associated with mental fatigue. After adjusting for age, sex, body mass index, hypertension, previous myocardial infarction, heart failure, diabetes, New York Heart Association functional class, depressive symptoms, and anxiety symptoms, lower free T3 concentrations remained associated with physical fatigue (β = -.224, p = .03); lower free T(4) concentrations, with exertion fatigue (β = -.219, p = .03); and lower morning cortisol and lower ΔCortisol concentrations, with mental fatigue (β = -.193 [p = .03] and β = -.180 [p =.04], respectively). Exercise capacity was not associated with endocrine factors.ConclusionsIn coronary artery disease patients, increased thyroid hormone concentrations are associated with decreased physical fatigue and decreased exertion fatigue, and increased cortisol concentrations with decreased mental fatigue. Exercise capacity is not associated with endocrine factors.
Adomas Bunevicius; Vilte Gintauskiene; Aurelija Podlipskyte; Remigijus Zaliunas; Julija Brozaitiene; Arthur J Prange; Robertas Bunevicius
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Psychosomatic medicine     Volume:  -     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Behavioral Medicine Institute, Lithuanian University of Health Sciences, Palanga, Lithuania (A.B., V.G., A.P., J.B., R.B.); Departments of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, California (A.B., A.J.P.); and Clinic of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania (R.Z.).
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