Document Detail

Fatigue and depressive symptoms associated with chronic viral hepatitis patients. health-related quality of life (HRQOL).
MedLine Citation:
PMID:  21057161     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND RATIONALE: It is well established that chronic viral hepatitis (CVH) negatively affects patients . health-related quality of life (HRQOL). The aim of the present study was to assess the extent to which fatigue and depressive symptoms are associated with CVH patients. HRQOL.
METHODS: Eighty-four adult CVH outpatients [45 with hepatitis B virus (HBV) and 39 with hepatitis C virus (HCV) infection] participated in the study. The Short Form-36 Health Survey (SF-36), the Beck Depression Inventory-II (BDI-II) and the Fatigue subscale of the Functional Assessment of Cancer Therapy-Anemia Scale (FACT-F) were used to assess HRQOL, depression and fatigue, respectively.
RESULTS: All aspects of HRQOL perceived by CVH patients were significantly impaired compared to the general population, as a comparison with Greek population-based normative data revealed. HBV patients presented similar HRQOL with HCV patients. Clinical parameters including infection activity, fibrosis stage or inflammation grade, as well as depressive symptoms and fatigue were found to be significantly associated with HRQOL. Multivariate analyses showed that older age (p <0.001) and higher fatigue scores (p <0.001) were the variables most closely associated with the physical HRQOL, whereas higher rates on depressive symptoms (p <0.0005) and fatigue (p <0.020) scales were the variables most closely associated with the mental HRQOL.
CONCLUSIONS: In conclusion, CVH is associated with impaired HRQOL. Fatigue and impaired psychological functioning is associated with diminished HRQOL in CHV, independent of the disease etiology. Consequently, management of fatigue and depressive symptoms should be considered a priority, in order to improve HRQOL in CVH patients.
Katerina Karaivazoglou; Gregoris Iconomou; Christos Triantos; Thomas Hyphantis; Konstantinos Thomopoulos; Maria Lagadinou; Charalambos Gogos; Chryssoula Labropoulou-Karatza; Konstantinos Assimakopoulos
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of hepatology     Volume:  9     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2010 Oct-Dec
Date Detail:
Created Date:  2010-11-08     Completed Date:  2011-02-17     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  419-27     Citation Subset:  IM    
Department of Psychiatry, University of Patras School of Medicine, Rion Patras, Greece.
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MeSH Terms
Depression / epidemiology,  psychology*
Fatigue / epidemiology,  psychology*
Health Surveys
Hepatitis B, Chronic / psychology*
Hepatitis C, Chronic / psychology*
Middle Aged
Multivariate Analysis
Quality of Life / psychology*

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