| Fatigue of airway obstruction during long-term exposure to allergen aerosol. | |
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MedLine Citation:
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PMID: 594497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The response to prolonged antigen exposure and the potentiation of airway resistance increase to ACH challenge, after this exposure, were studied on sixteen boxer dogs. One group of animals presented fatigue to A.E. after 3 hours of exposure. This group developed an increased response to ACH aerosol after fatigue to antigen was present. In a second group of dogs, absence of fatigue during prolonged exposure to allergen was observed. A growing tendency of Edyn (as an index of airway resistance) was observed after 5 hours of exposure. The therapeutical influence of bilateral vagus blockade was tested in these last animals. Blockade of nervus vagus released airway obstruction during prolonged allergen exposure and no bronchoconstriction was observed after ACH challenge during blockade. |
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Authors:
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I Zimmermann; P Curschmann; J Kowalski; W T Ulmer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie Volume: 171 ISSN: 0300-9130 ISO Abbreviation: Res Exp Med (Berl) Publication Date: 1977 Dec |
Date Detail:
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Created Date: 1978-02-18 Completed Date: 1978-02-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0324736 Medline TA: Res Exp Med (Berl) Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 219-28 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Aerosols Airway Obstruction / etiology* Allergens* Animals Ascaris / immunology Dogs Fatigue / etiology* Tidal Volume Time Factors Vagus Nerve / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Allergens; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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