Document Detail

Fatigue after aneurysmal subarachnoid hemorrhage evaluated by pituitary function and 3D-CBF.
MedLine Citation:
PMID:  14705969     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The reason for longstanding fatigue following aneurysmal subarachnoidal hemorrhage (SAH) is still not clarified. The bleed from supratentorial aneurysms is often in the vicinity of the hypothalamus and pituitary gland making an endocrine dysfunction plausible. METHODS: Ten patients with post-SAH fatigue were investigated with 3D-CBF (SPECT) and underwent an evaluation of the pituitary function. RESULTS: Five had normal pituitary function. Disturbances in the gonadotropin function was detected in three patients and suspected in two. The mean insulin-like growth factor I (IGF-I) value of the patients was in the lower part of the reference range. In the patients with endocrine dysfunction, the 3D-CBF was pathologic in the central structures of the basal region. CONCLUSIONS: The present results indicate that an aneurysmal SAH may result in partially impaired pituitary capacity. This deficit may contribute to fatigue after aneurysmal SAH, but cannot solely explain this disorder. SPECT identified regional tissue damage in the patients with pituitary dysfunction after SAH.
L Brandt; H Säveland; S Valdemarsson; H Sjöholm; P Reinstrup
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  109     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-06     Completed Date:  2004-02-27     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  91-6     Citation Subset:  IM    
Department of Neurosurgery, University Hospital of Lund, Lund, Sweden.
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MeSH Terms
Fatigue / etiology*
Imaging, Three-Dimensional
Insulin-Like Growth Factor I / analysis
Middle Aged
Pituitary Gland / blood supply*,  pathology*,  radionuclide imaging
Regional Blood Flow
Subarachnoid Hemorrhage / complications*
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I

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