Document Detail

Fatigue, depression, sleep, and activity during chemotherapy: daily and intraday variation and relationships among symptom changes.
MedLine Citation:
PMID:  21785899     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous research suggests that cancer patients frequently experience multiple symptoms during chemotherapy; however, relationships among symptom changes are largely unknown.
PURPOSE: The aim of the current study was to examine daily and intraday changes and interrelationships among fatigue, depression, and objectively measured disruptions in sleep and activity during chemotherapy.
METHODS: Participants were 78 women with gynecologic cancer. Fatigue, depression, sleep, and activity were assessed the week before and the week after the participants' first three infusions.
RESULTS: Significant changes in fatigue, depression, sleep, and activity were observed over time. Before infusions, increases in fatigue were associated with increases in depression. After infusions, increases in fatigue were associated with increases in depression and minutes awake at night, as well as decreases in daytime activity and regularity of sleep/activity patterns (ps < .05).
CONCLUSIONS: This study is among the first to track daily and intraday changes in symptoms and interrelationships during chemotherapy. Results indicate that symptoms are interrelated and return to baseline levels after infusions.
Heather S L Jim; Brent Small; Leigh Anne Faul; Jamie Franzen; Sachin Apte; Paul B Jacobsen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Annals of behavioral medicine : a publication of the Society of Behavioral Medicine     Volume:  42     ISSN:  1532-4796     ISO Abbreviation:  Ann Behav Med     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-17     Completed Date:  2012-03-01     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8510246     Medline TA:  Ann Behav Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-33     Citation Subset:  IM    
Moffitt Cancer Center, Tampa, FL 33612, USA.
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MeSH Terms
Activities of Daily Living*
Antineoplastic Agents / adverse effects*,  therapeutic use
Chemotherapy, Adjuvant
Cohort Studies
Depression / etiology*,  psychology
Genital Neoplasms, Female / complications,  drug therapy*,  psychology*
Middle Aged
Sleep Initiation and Maintenance Disorders / etiology*,  psychology
Socioeconomic Factors
Stress, Psychological / etiology
Grant Support
K07 CA138499/CA/NCI NIH HHS; K07-138499//PHS HHS; R03 CA126775/CA/NCI NIH HHS; R03-126775//PHS HHS
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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