Document Detail


Fate mapping of the mouse prosencephalic neural plate.
MedLine Citation:
PMID:  10694429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Little is known about the behavior of cells within the anterior neural plate or tube in developing mammalian embryos in utero due to technical limitations. Here we labeled neuroepithelial cells with vital dye and traced their siblings for 1 or 2 days using the whole-embryo culture system. The results demonstrated that rostral cell movement from the midbrain to the forebrain in the mouse neural plate was restricted at the boundary by the five-somite stage. Coincident with restriction of cell intermingling, expression of a transcription factor, Pax6, and a cell adhesion molecule, cadherin-6, commmenced to demarcate the forebrain compartment. Within this compartment, we also mapped several prospective regions of the telencephalon and diencephalon to the eyes. The fate map of the mouse prosencephalic neural plate was very similar to those of other vertebrates, providing evidence that mammalian-specific brain structures, represented in the cerebral neocortex, could evenly develop along the conserved framework of neuromeres.
Authors:
T Inoue; S Nakamura; N Osumi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental biology     Volume:  219     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-03     Completed Date:  2000-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  373-83     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Affiliation:
Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Cadherins / genetics
Cell Movement
Coloring Agents
Culture Techniques
DNA-Binding Proteins / genetics
Evolution
Eye Proteins
Gene Expression Regulation, Developmental
Homeodomain Proteins*
Mice
Mice, Inbred ICR
Models, Neurological
Molecular Sequence Data
Neural Crest / cytology,  embryology
Paired Box Transcription Factors
Prosencephalon / cytology,  embryology*
Repressor Proteins
Somites / cytology
Chemical
Reg. No./Substance:
0/Cadherins; 0/Coloring Agents; 0/DNA-Binding Proteins; 0/Eye Proteins; 0/Homeodomain Proteins; 0/K cadherin; 0/PAX6 protein; 0/Paired Box Transcription Factors; 0/Repressor Proteins

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