| Fate mapping of the mouse prosencephalic neural plate. | |
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MedLine Citation:
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PMID: 10694429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Little is known about the behavior of cells within the anterior neural plate or tube in developing mammalian embryos in utero due to technical limitations. Here we labeled neuroepithelial cells with vital dye and traced their siblings for 1 or 2 days using the whole-embryo culture system. The results demonstrated that rostral cell movement from the midbrain to the forebrain in the mouse neural plate was restricted at the boundary by the five-somite stage. Coincident with restriction of cell intermingling, expression of a transcription factor, Pax6, and a cell adhesion molecule, cadherin-6, commmenced to demarcate the forebrain compartment. Within this compartment, we also mapped several prospective regions of the telencephalon and diencephalon to the eyes. The fate map of the mouse prosencephalic neural plate was very similar to those of other vertebrates, providing evidence that mammalian-specific brain structures, represented in the cerebral neocortex, could evenly develop along the conserved framework of neuromeres. |
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Authors:
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T Inoue; S Nakamura; N Osumi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental biology Volume: 219 ISSN: 0012-1606 ISO Abbreviation: Dev. Biol. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-04-03 Completed Date: 2000-04-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 373-83 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Academic Press. |
Affiliation:
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Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Cadherins / genetics Cell Movement Coloring Agents Culture Techniques DNA-Binding Proteins / genetics Evolution Eye Proteins Gene Expression Regulation, Developmental Homeodomain Proteins* Mice Mice, Inbred ICR Models, Neurological Molecular Sequence Data Neural Crest / cytology, embryology Paired Box Transcription Factors Prosencephalon / cytology, embryology* Repressor Proteins Somites / cytology |
| Chemical | |
Reg. No./Substance:
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0/Cadherins; 0/Coloring Agents; 0/DNA-Binding Proteins; 0/Eye Proteins; 0/Homeodomain Proteins; 0/K cadherin; 0/PAX6 protein; 0/Paired Box Transcription Factors; 0/Repressor Proteins |
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