Document Detail

Fate of PCDF/PCB congeners and change of clinical symptoms in patients with Yusho PCB poisoning for 30 years.
MedLine Citation:
PMID:  11372885     Owner:  NLM     Status:  MEDLINE    
Two mass-food poisonings called Yusho and Yucheng occurred in Japan and Taiwan in 1968 and 1979, respectively. Blood samples from five Yusho patients and three Yucheng patients were collected several times from 1982 to 1998 and from 1980 to 1995, respectively, and analyzed for polychlorinated dibenzofurans (PCDF) and polychlorinated biphenyls (PCB) congeners. Fat base concentrations of 2,3,4,7,8-penta-CDF in the Yusho patients, which were responsible for about 70% of the dioxin toxicity, are estimated to be decreased from 60 ppb in 1969 to 800 ppt in 1997 with the median half-life of 2.9 years in the first 15 years after onset and 7.7 years in the next stage of 15 years. Typical Yusho symptoms of acneiform eruption, dermal pigmentation and increased eye discharge were very gradually recovered with lapse of several years. However, enzyme and/or hormone-mediated signs of high serum triglyceride, high serum thyroxin, immunoglobulin disorder and others are persistently maintained for 30 years.
Y Masuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemosphere     Volume:  43     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-05-24     Completed Date:  2001-09-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  925-30     Citation Subset:  IM    
Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan.
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MeSH Terms
Acne Vulgaris / chemically induced,  pathology
Benzofurans / analysis,  pharmacokinetics*
Environmental Pollutants / pharmacokinetics,  poisoning*
Eye Diseases / pathology
Follow-Up Studies
Food Contamination*
Immunoglobulins / analysis
Middle Aged
Polychlorinated Biphenyls / poisoning*
Skin Pigmentation
Thyroxine / blood
Triglycerides / blood
Reg. No./Substance:
0/Benzofurans; 0/Environmental Pollutants; 0/Immunoglobulins; 0/Polychlorinated Biphenyls; 0/Triglycerides; 0/chlorinated dibenzofurans; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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