| Fatality complicating agranulocytosis in the setting of carbimazole therapy. | |
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MedLine Citation:
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PMID: 19291446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carbimazole is an antithyroid drug of the thionamide class which is used in the treatment of hyperthyroidism. Rarely, use of this drug may be associated with the development of agranulocytosis and neutropenia with the consequent risk of sepsis. We present the case of a 50-year-old female who developed rapidly progressive Pseudomonas aeruginosa septicemia in the setting of panycytopenia approximately 4 weeks following the commencement of carbimazole therapy for Graves' disease. She died shortly after presentation to hospital and the case was referred to the coroner as the death was unexpected and the clinical course was considered unusual. Relatively sudden, unexpected deaths resulting from hematological/endocrine causes are uncommonly encountered by forensic pathologists and this case serves to illustrate the enduring value of the autopsy in providing important clinicopathological correlation to clinicians. |
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Authors:
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Matthew J Lynch; Noel W F Woodford |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-05-14 |
Journal Detail:
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Title: Forensic science, medicine, and pathology Volume: 4 ISSN: 1547-769X ISO Abbreviation: - Publication Date: 2008 |
Date Detail:
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Created Date: 2009-03-17 Completed Date: 2009-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101236111 Medline TA: Forensic Sci Med Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 246-9 Citation Subset: IM |
Affiliation:
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Victorian Institute of Forensic Medicine, 57-83 Kavanagh Street, Southbank, VIC 3006, Australia. matthewl@vifm.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Agranulocytosis
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chemically induced* Antithyroid Agents / administration & dosage, adverse effects* Carbimazole / administration & dosage, adverse effects* Fatal Outcome Female Forensic Pathology Graves Disease / drug therapy Humans Middle Aged Pancytopenia / chemically induced, complications Pseudomonas Infections / etiology Sepsis / microbiology |
| Chemical | |
Reg. No./Substance:
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0/Antithyroid Agents; 22232-54-8/Carbimazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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