Document Detail


Fatal susceptibility to cycloheximide of mice bearing Ehrlich ascites tumours and of animals pretreated with cell-free Ehrlich ascites tumour fluid.
MedLine Citation:
PMID:  3204165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Soluble, but unidentified, factors in cell-free Ehrlich ascites tumour fluid induced, after a delay period, a fatal heparin- and ancrod-resistant susceptibility to a normally tolerated dose of cycloheximide. The evidence suggests that production of such factors is dependent upon interaction of tumour cells with the intravascular or the intraperitoneal compartment. The factors are considered likely also to play a crucial role in the similar heparin and ancrod-resistant fatalities which follow cycloheximide challenge of mice bearing established Ehrlich ascites tumours and in the deaths of mice challenged with cycloheximide 24 h after an intravenous injection of washed Ehrlich ascites tumour cells. These factors play no part in the heparin- and ancrod-preventable fatal syndrome following cycloheximide challenge either 2 h before or 2 h after intravenous injection of washed Ehrlich ascites tumour cells.
Authors:
E W Parry
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of comparative pathology     Volume:  99     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-02-07     Completed Date:  1989-02-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  309-15     Citation Subset:  IM    
Affiliation:
Department of Human Anatomy and Cell Biology, The University, Liverpool, U.K.
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MeSH Terms
Descriptor/Qualifier:
Ancrod / pharmacology
Animals
Carcinoma, Ehrlich Tumor / metabolism*,  pathology
Cycloheximide / toxicity*
Heparin / pharmacology
Intestine, Small / pathology
Liver / pathology
Male
Mice
Mice, Inbred CBA
Time Factors
Chemical
Reg. No./Substance:
66-81-9/Cycloheximide; 9005-49-6/Heparin; EC 3.4.21.-/Ancrod

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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