Document Detail


Fatal spontaneous subdural bleeding due to neonatal giant cell hepatitis: a rare differential diagnosis of shaken baby syndrome.
MedLine Citation:
PMID:  21331818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 7-week-old girl showed vomiting after feeding, facial pallor, loss of muscle tone and respiratory depression. An emergency doctor performed successful resuscitation and after arrival in hospital, cranial ultrasound showed left-sided subdural hemorrhage, cerebral edema with a shift of the midline, and a decrease in cerebral perfusion. Ophthalmologic examination showed retinal hemorrhage. In view of this, the doctors suspected shaken baby syndrome and approached the parents with their suspicions, but they denied any shaking or trauma. Despite surgery for the subdural hemorrhage the girl died a few hours later with a severe coagulopathy. Autopsy verified subdural hemorrhage, cerebral edema and retinal hemorrhage, but also revealed intact bridging veins and a lack of optic nerve sheath hemorrhage, therefore shaken baby syndrome could not be proven by autopsy. Histological examination showed severe neonatal giant cell hepatitis as the cause of the severe coagulopathy and the associated spontaneous subdural bleeding. Neonatal giant cell hepatitis may be responsible for unexpected deaths in infancy and, although rarely associated with subdural bleeding, must be considered as a potential differential diagnosis of shaken baby syndrome.
Authors:
Saskia S Guddat; Edwin Ehrlich; Hubert Martin; Michael Tsokos
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-02-18
Journal Detail:
Title:  Forensic science, medicine, and pathology     Volume:  7     ISSN:  1556-2891     ISO Abbreviation:  Forensic Sci Med Pathol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-07-29     Completed Date:  2011-12-29     Revised Date:  2012-02-29    
Medline Journal Info:
Nlm Unique ID:  101236111     Medline TA:  Forensic Sci Med Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  294-7     Citation Subset:  IM    
Affiliation:
Institute of Legal Medicine and Forensic Sciences, Charité-Universitätsmedizin Berlin, Turmstr. 21 (Haus L), 10559, Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Brain Edema / etiology,  pathology
Diagnosis, Differential
Female
Forensic Pathology
Giant Cells / pathology*
Hematoma, Subdural / etiology*,  pathology
Hepatitis / congenital*,  pathology*
Humans
Infant
Retinal Hemorrhage / etiology,  pathology
Shaken Baby Syndrome / diagnosis
Comments/Corrections
Comment In:
Forensic Sci Med Pathol. 2012 Mar;8(1):79; author reply 80   [PMID:  21948236 ]
Forensic Sci Med Pathol. 2011 Sep;7(3):298-300   [PMID:  21479950 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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