Document Detail

Fatal splenic rupture in a pregnant woman with hemoglobin C/beta-thalassemia and myeloid metaplasia.
MedLine Citation:
PMID:  16879031     Owner:  NLM     Status:  MEDLINE    
Splenic rupture with intraperitoneal hemorrhage is a fatal condition that is rarely encountered during the third trimester of pregnancy; its pathogenetic mechanisms and causes are largely unknown. We report a case of splenic rupture in a pregnant woman that caused the death of the mother and child. The patient was a carrier of double heterozygosis for hemoglobin C/beta-thalassemia. Spleen and liver enlargement due to extramedullary hematopoiesis was found at autopsy. Our data suggest that rare and hidden hematologic disorders should be considered as possible causes of splenic enlargement and rupture during pregnancy.
Renzo Boldorini; Cristina Bozzola; Eleonora Gallarotti; Raffaella Ribaldone
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  130     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-01     Completed Date:  2006-08-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1231-2     Citation Subset:  AIM; IM    
Department of Medical Science, University School of Medicine Amedeo Avogadro of Eastern Piedmon, Novara, Italy.
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MeSH Terms
Fatal Outcome
Fetal Death*
Hemoglobin C / analysis*
Hemorrhage / etiology,  pathology
Peritoneal Diseases / etiology,  pathology
Pregnancy Complications, Hematologic*
Pregnancy Trimester, Second
Primary Myelofibrosis / complications*,  pathology
Splenic Rupture / etiology*,  pathology
beta-Thalassemia / complications*,  genetics,  pathology
Reg. No./Substance:
9008-00-8/Hemoglobin C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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