Document Detail

Fatal pulmonary hypersensitivity reaction to HL-A incompatible blood transfusion:report of a case and review of the literature.
MedLine Citation:
PMID:  1258114     Owner:  NLM     Status:  MEDLINE    
A girl with Thalassemia major reacted to a transfusion of packed red blood cells with increasing respiratory distress until death 12 1/2 hours later. Chills and fever were followed by dry cough, dyspnea, and pulmonary edema. The recipient had lymphocytotoxic antibodies specific for donor leukocyte antigens HL-A11 and possibly W14. At autopsy, the lungs showed pulmonary edema with extensive nonspecific acute alveolar injury. Similar cases in the literature are reviewed.
C F Wolf; V C Canale
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Transfusion     Volume:  16     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:    1976 Mar-Apr
Date Detail:
Created Date:  1976-06-02     Completed Date:  1976-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  135-40     Citation Subset:  IM    
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MeSH Terms
Blood Group Incompatibility / complications*
Blood Transfusion*
Histocompatibility Antigens*
Pulmonary Edema / etiology,  pathology
Respiratory Hypersensitivity / etiology*
Thalassemia / therapy
Reg. No./Substance:
0/Histocompatibility Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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