Document Detail


Fatal pulmonary haemorrhage with the combined use of abciximab and fibrinolytic agent.
MedLine Citation:
PMID:  12680530     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The increased bleeding risk associated with the use of abciximab has been well reported. The risk appears to be amplified when abciximab is administered concurrently with a fibrinolytic agent. We report and review the literature on the occurrence of a case of fatal pulmonary haemorrhage, a rare bleeding complication, in a patient who received both these drugs.
Authors:
H C Tan; A Low; K S Ng; B Budiono; A Sutandar; B L Chia; Y T Lim
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Singapore medical journal     Volume:  43     ISSN:  0037-5675     ISO Abbreviation:  Singapore Med J     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2003-04-08     Completed Date:  2003-05-08     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0404516     Medline TA:  Singapore Med J     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  587-9     Citation Subset:  IM    
Affiliation:
Cardiac Department, National University Hospital, 5 Lower Kent, Ridge Road, Singapore 119074. tanhc@nuh.com.sg
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal / adverse effects*
Drug Therapy, Combination
Fatal Outcome
Fibrinolytic Agents / adverse effects*
Hemorrhage / chemically induced*
Humans
Immunoglobulin Fab Fragments / adverse effects*
Lung Diseases / chemically induced*
Male
Middle Aged
Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors
Streptokinase / adverse effects*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Fibrinolytic Agents; 0/Immunoglobulin Fab Fragments; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 143653-53-6/abciximab; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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