| Fatal pulmonary fibrosis after rituximab administration. | |
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MedLine Citation:
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PMID: 19396468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Idiopathic nephrotic syndrome is the most frequent glomerular disease during childhood. Although immunosuppressive agents are usually effective, some severe cases remain difficult to treat. We describe a female patient with secondary steroid-resistant nephrotic syndrome who no longer responded to conventional treatment. Owing to cyclosporine toxicity, rituximab was administered. Three days after treatment the patient's clinical condition dramatically worsened and she developed acute respiratory distress. Despite all means used to treat her, she died 5 weeks after rituximab infusion. A pulmonary biopsy showed extensive fibrosis, while the alveolar epithelium was no longer visible. |
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Authors:
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Marie-Camille Chaumais; Arnaud Garnier; Fran?ois Chalard; Michel Peuchmaur; Stephane Dauger; Evelyne Jacqz-Agrain; Georges Desch?nes |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-04-25 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 24 ISSN: 1432-198X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2009-10-08 Revised Date: 2010-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 1753-5 Citation Subset: IM |
Affiliation:
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Department of Pediatric Pharmacology and Pharmacogenetics, Robert Debr? Hospital, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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adverse effects* Child Fatal Outcome Female Humans Immunologic Factors / adverse effects* Nephrotic Syndrome / complications, drug therapy*, pathology Pulmonary Fibrosis / chemically induced*, pathology, physiopathology Respiratory Insufficiency / chemically induced, pathology, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Immunologic Factors; 0/rituximab |
| Comments/Corrections | |
Comment In:
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Pediatr Nephrol. 2010 Jun;25(6):1193
[PMID:
20024586
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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