Document Detail


Fatal propafenone overdoses: case reports and a review of the literature.
MedLine Citation:
PMID:  14670140     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
First synthesized in 1970, propafenone is a frequently used 1C antiarrhythmic drug metabolized into two major metabolites, 5-hydroxypropafenone and norpropafenone. Paradoxically, fatal intoxication is rarely described, and only six cases have been reported in the literature. We report our experience with two patients found dead of self-inflicted poisoning where the propafenone blood concentration was very high (one concentration to our knowledge is one of the highest reported in the literature). At autopsy, no evidence of significant pathological disease were found. Propafenone was detected in blood by gas chromatography-mass spectrometry and by high-performance liquid chromatography using a diode-array detector, respectively, as propafenone artifact and propafenone. Blood propafenone concentrations were 4180 ng/mL and 9123 ng/mL. The literature regarding propafenone pharmacokinetic and intoxication is reviewed, and we discuss the low death rate attributed to this drug in contrast to its frequent use.
Authors:
Franck Clarot; Jean Pierre Goullé; Marlène Horst; Emmanuelle Vaz; Christian Lacroix; Bernard Proust
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of analytical toxicology     Volume:  27     ISSN:  0146-4760     ISO Abbreviation:  J Anal Toxicol     Publication Date:    2003 Nov-Dec
Date Detail:
Created Date:  2003-12-12     Completed Date:  2004-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705085     Medline TA:  J Anal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  595-9     Citation Subset:  IM    
Affiliation:
Medical Forensic Institute, Rouen University Hospital Charles Nicolle, Rouen, France. franck.clarot@chu-rouen.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Arrhythmia Agents / blood,  poisoning*,  urine
Fatal Outcome
Gas Chromatography-Mass Spectrometry
Humans
Male
Methanol / blood
Middle Aged
Overdose
Propafenone / blood,  poisoning*,  urine
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 54063-53-5/Propafenone; 67-56-1/Methanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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