Document Detail

Fatal polyarteritis nodosa with gastrointestinal involvement in a child.
MedLine Citation:
PMID:  17198214     Owner:  NLM     Status:  MEDLINE    
Polyarteritis nodosa (PAN) is a necrotizing angiitis that predominantly affects small- and medium-sized arteries. Polyarteritis nodosa occurs rarely during childhood. Boys and girls seem to be equally affected, with a peak at the age of 10 years. Rarely, severe and fatal gastrointestinal involvement is seen in PAN. Here, we report a 15-year-old boy with PAN, who had gastrointestinal involvement with multiple aneurysms of the hepatic and superior mesenteric arteries. This involvement could be demonstrated with conventional angiography and gastrointestinal bleeding scintigraphy. The progression of the symptoms and the decrease in the size of the aneurysms were noted after combination treatment with cyclophosphamide and prednisolone, but there was severe bleeding from small bowel, and it was taken under control by resection of jejunum. However, the patient died because of sepsis. In conclusion, severe gastrointestinal involvement in PAN is usually fatal despite aggressive therapy, as is the case in our patient.
Tanl Kendirli; Selçuk Yüksel; Mehmet Oral; Necmettin Unal; Melek Tulunay; Umman Sanl Dilek; Fatoş Yalçnkaya
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric emergency care     Volume:  22     ISSN:  1535-1815     ISO Abbreviation:  Pediatr Emerg Care     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507560     Medline TA:  Pediatr Emerg Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  810-2     Citation Subset:  IM    
Division of Pediatric Intensive Care Unit, Ankara University School of Medicine, Dikimevi, Ankara, Turkey.
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MeSH Terms
Aneurysm / etiology*,  surgery
Fatal Outcome
Gastrointestinal Diseases / complications*,  therapy
Hepatic Artery*
Mesenteric Artery, Superior*
Polyarteritis Nodosa / complications*,  therapy
Sepsis / drug therapy,  microbiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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