Document Detail


Fatal poisoning with a new phenylethylamine: 4-methylthioamphetamine (4-MTA).
MedLine Citation:
PMID:  10732944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There has been much publicity in the United Kingdom regarding a new phenylethylamine-based compound called 4-methylthioamphetamine (4-MTA), also known as para-methylthioamphetamine (p-MTA), MTA or "Flatliner". Chemically, 4-MTA is an amphetamine derivative and is a non-neurotoxic potent serotonin-releasing agent and reversible inhibitor of rat monoamine oxidase-A. Analysis of postmortem blood and urine specimens in a case implicating 3,4-methylenedioxymethamphetamine revealed the presence of 4-MTA at a concentration of 4.6 mg/L in femoral blood and 87.2 mg/l in the urine. The concentration of 4-MTA in perimortem blood was measured at 4.2 mg/L. This is the first reported case of death involving 4-MTA in the United Kingdom and the first case known to involve 4-MTA only.
Authors:
S P Elliott
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of analytical toxicology     Volume:  24     ISSN:  0146-4760     ISO Abbreviation:  J Anal Toxicol     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-11     Completed Date:  2000-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705085     Medline TA:  J Anal Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  IM    
Affiliation:
Regional Laboratory for Toxicology, City Hospital N.H.S. Teaching Trust, Birmingham, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amphetamines / metabolism,  poisoning*
Enzyme Multiplied Immunoassay Technique
Fatal Outcome
Gas Chromatography-Mass Spectrometry
Humans
Male
Poisoning / blood*,  urine*
Serotonin Uptake Inhibitors / metabolism,  poisoning*
Substance Abuse Detection / methods
Chemical
Reg. No./Substance:
0/Amphetamines; 0/Serotonin Uptake Inhibitors; 14116-06-4/4-methylthioamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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