Document Detail

Fatal parasitic meningoencephalomyelitis caused by Halicephalobus deletrix : a case report and review of the literature.
MedLine Citation:
PMID:  20367314     Owner:  NLM     Status:  MEDLINE    
Infection with the saprophagous nematode Halicephalobus species is uncommon but has been reported in horses worldwide. Only 3 human cases have been previously described, all of which have been fatal. We report a fourth fatal case, which occurred in a 39-year-old woman who presented with meningeal signs, altered mental status, and a prodromal pruritic rash. Diagnostic evaluation included an open brain biopsy, which was diagnosed as granulomatous vasculitis. The patient subsequently died after a course of steroids and cyclophosphamide. At autopsy, a robust perivascular mixed inflammatory infiltration of the brain parenchyma, meninges, and ventricular system was present with larval forms and mature nematodes morphologically consistent with Halicephalobus deletrix . Although extremely rare, this organism needs to be considered in the differential diagnosis of human helminthic infection of the central nervous system.
Sarah L Ondrejka; Gary W Procop; Keith K Lai; Richard A Prayson
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  134     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-06     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  625-9     Citation Subset:  AIM; IM    
Department of Pathology and Laboratory Medicine, Cleveland Clinic, Ohio 44195, USA.
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MeSH Terms
Brain / parasitology,  pathology
Diagnosis, Differential
Encephalomyelitis / diagnosis,  parasitology*
Fatal Outcome
Meningoencephalitis / diagnosis,  parasitology*
Rhabditida / isolation & purification,  pathogenicity
Rhabditida Infections / diagnosis,  parasitology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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