| Fatal parasitic meningoencephalomyelitis caused by Halicephalobus deletrix : a case report and review of the literature. | |
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MedLine Citation:
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PMID: 20367314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infection with the saprophagous nematode Halicephalobus species is uncommon but has been reported in horses worldwide. Only 3 human cases have been previously described, all of which have been fatal. We report a fourth fatal case, which occurred in a 39-year-old woman who presented with meningeal signs, altered mental status, and a prodromal pruritic rash. Diagnostic evaluation included an open brain biopsy, which was diagnosed as granulomatous vasculitis. The patient subsequently died after a course of steroids and cyclophosphamide. At autopsy, a robust perivascular mixed inflammatory infiltration of the brain parenchyma, meninges, and ventricular system was present with larval forms and mature nematodes morphologically consistent with Halicephalobus deletrix . Although extremely rare, this organism needs to be considered in the differential diagnosis of human helminthic infection of the central nervous system. |
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Authors:
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Sarah L Ondrejka; Gary W Procop; Keith K Lai; Richard A Prayson |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 134 ISSN: 1543-2165 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-06 Completed Date: 2010-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: United States |
Other Details:
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Languages: eng Pagination: 625-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Cleveland Clinic, Ohio 44195, USA. ondrejs@ccf.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Brain / parasitology, pathology Diagnosis, Differential Encephalomyelitis / diagnosis, parasitology* Fatal Outcome Female Humans Meningoencephalitis / diagnosis, parasitology* Rhabditida / isolation & purification, pathogenicity Rhabditida Infections / diagnosis, parasitology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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