Document Detail


Fatal overdose of amphotericin B in two preterm infants.
MedLine Citation:
PMID:  1841836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two premature infants exhibited an acute cardiorespiratory collapse shortly after receiving a 50-fold overdose of amphotericin B (AmB). Despite aggressive intervention both infants died. Serum AmB levels were double the normal therapeutic range. We speculate that two less well-recognized toxic complications of AmB involving the cardiac and respiratory systems may have contributed to the fatal outcome.
Authors:
J M Perlman; M Acarregui; J W Gard
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  17     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1991  
Date Detail:
Created Date:  1992-12-03     Completed Date:  1992-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  187-90     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, UT Southwestern Medical Center, Dallas.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Amphotericin B / poisoning*
Dose-Response Relationship, Drug
Female
Humans
Infant, Newborn
Infant, Premature / physiology*
Male
Chemical
Reg. No./Substance:
1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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