Document Detail

Fatal neonatal renal failure due to maternal enalapril ingestion.
MedLine Citation:
PMID:  16147831     Owner:  NLM     Status:  MEDLINE    
CASE: The index case was born to a mother with PIH which was treated with enalapril (5 mg) once a day for 21 days prior to delivery in addition to other anti-hypertensives. Temporally, use of enalapril was associated with the onset of oligohydramnios. The neonate presented with intrauterine growth retardation, hydrops and oliguric renal failure, which did not respond to furosemide, peritoneal dialysis and exchange transfusion. Autopsy showed macroscopically and microscopically normal kidneys.
CONCLUSION: Use of ACE inhibitors during pregnancy should be avoided.
Srinivas Murki; Praveen Kumar; Sourabh Dutta; Anil Narang
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  17     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-09-08     Completed Date:  2005-12-01     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  235-7     Citation Subset:  IM    
National unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Acute Kidney Injury / chemically induced,  diagnosis*,  embryology
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  adverse effects*
Diagnosis, Differential
Enalapril / administration & dosage,  adverse effects*
Fatal Outcome
Hypertension / drug therapy*
Infant, Newborn
Pregnancy Complications, Cardiovascular / drug therapy*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 75847-73-3/Enalapril

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