Document Detail

Fatal neonatal parechovirus encephalitis.
MedLine Citation:
PMID:  22171236     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Two infants developed encephalitis in the late neonatal period due to human parechovirus type 3 (HPeV-3). This finally resulted in intractable seizures leading to death. Both presented with classical signs and symptoms. HPeV-3 was detected in nasopharyngeal and rectal swabs, cerebrospinal fluid, serum and postmortem samples (for one infant). Ultrasound and magnetic resonance imaging findings showed severe white matter injury in one infant, and limited hippocampal injury in the other. Parents consented to autopsy in the latter, showing diffuse gliotic oedema of cerebral white matter, bilateral bronchopneumonia, and inflammation in spleen. We emphasise that polymerase chain reaction (PCR) testing for parechovirus in neonates with severe sepsis-like syndrome and meningoencephalitis is mandatory.
Arjen L van Zwol; Maarten Lequin; Coranne Aarts-Tesselaar; Annemiek A van der Eijk; Gertjan A Driessen; Matthijs de Hoog; Paul Govaert
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Publication Detail:
Type:  Journal Article     Date:  2009-12-14
Journal Detail:
Title:  BMJ case reports     Volume:  2009     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2009  
Date Detail:
Created Date:  2011-12-15     Completed Date:  2012-10-02     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  -    
Erasmus Medical Centre, Sophia Children's Hospital, Neonatology, Dr Molewaterplein 60, 3015 GJ Rotterdam, Rotterdam, 3015GJ, Netherlands.
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