| Fatal myocarditis in mice fed rancid purified feed. | |
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MedLine Citation:
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PMID: 6716961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An outbreak of disease characterized by diarrhea, severe myocarditis, and high mortality occurred in a group of 800 male B6C3F1/ Har mice fed powdered purified diets. A total of 292 animals died. No evidence of an infectious agent was found, and the disease was reproduced in healthy mice by feeding the purified diets, suggesting a nutritional deficiency or toxicity. Analysis of the feed revealed adequate levels of vitamin E, reduced levels of thiamine, and elevated levels of lipoperoxide. It was concluded that mortality was due to myocarditis associated with the ingestion of rancid feed. |
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Authors:
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D F Kusewitt; J E Wagner; L W Dixon; P A Anderson |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Laboratory animal science Volume: 34 ISSN: 0023-6764 ISO Abbreviation: Lab. Anim. Sci. Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-06-21 Completed Date: 1984-06-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1266503 Medline TA: Lab Anim Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 70-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed
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analysis,
poisoning* Animals Disease Outbreaks / veterinary* Lipid Peroxides / poisoning* Male Mice Mice, Inbred ICR Mice, Inbred Strains* Myocarditis / epidemiology, etiology, veterinary* Rodent Diseases / epidemiology, etiology*, pathology Vitamin K Deficiency / veterinary |
| Grant Support | |
ID/Acronym/Agency:
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RR00471/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipid Peroxides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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