Document Detail


Fatal multidrug-resistant Acinetobacter baumannii sepsis in a patient with travel history and recent onset of systemic lupus erythematosus: a case report.
MedLine Citation:
PMID:  16815754     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Severe infections are a common cause of death in patients suffering from systemic lupus erythematosus (SLE). We here report on a fatal multidrug-resistant Acinetobacter baumannii sepsis in a patient with newly diagnosed SLE, who had to be treated with immunosuppressants due to lupus nephritis. Detailed analysis of the patient's history revealed that colonisation probably had occurred during a recent hospitalisation of the patient in the Mediterranean region. E-test analysis indicated that resistance to carbapenems was mediated by a plasmid-encoded metallo-beta-lactamase. We conclude that travel history including previously visited health care facilities always should be carefully considered for decisions on anti-infective therapy, as travel activities increasingly facilitate spread of antimicrobial resistances.
Authors:
P Weyrich; S Borgmann; F Mayer; P Heeg; R Riessen; I Kötter
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-07-03
Journal Detail:
Title:  International journal of hygiene and environmental health     Volume:  209     ISSN:  1438-4639     ISO Abbreviation:  Int J Hyg Environ Health     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2007-02-15     Revised Date:  2007-06-21    
Medline Journal Info:
Nlm Unique ID:  100898843     Medline TA:  Int J Hyg Environ Health     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  581-3     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine; University Hospital of Tübingen, Otfried-Müller-Str. 10, 72076 Tübingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acinetobacter Infections / microbiology*
Acinetobacter baumannii / drug effects*,  enzymology,  genetics
Adult
Anti-Bacterial Agents / pharmacology
Carbapenems / pharmacology
Drug Resistance, Multiple, Bacterial*
Fatal Outcome
Female
Greece
Humans
Lupus Erythematosus, Systemic / complications*
Sepsis / microbiology*
Travel*
beta-Lactamases / genetics
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Carbapenems; EC 3.5.2.6/beta-Lactamases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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