Document Detail

Fatal methemoglobinemia due to inhalation of isobutyl nitrite.
MedLine Citation:
PMID:  8145358     Owner:  NLM     Status:  MEDLINE    
Isobutyl nitrite is a popular recreational drug among both homosexuals and heterosexuals as it is alleged to enhance sexual pleasure and prolong orgasm. In contrast to the ingestion of this volatile nitrite, inhalation is associated only rarely with serious sequelae, though symptomatic methemoglobinemia may occur. The case reported is the first documented fatality from inhalation of isobutyl nitrite. The widespread use of isobutyl nitrite is a cause for concern and physicians should be aware of the potentially fatal consequence of abuse, particularly in those with ischemic heart disease, and its management.
S M Bradberry; R M Whittington; D A Parry; J A Vale
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  32     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1994  
Date Detail:
Created Date:  1994-05-04     Completed Date:  1994-05-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  AIM; IM    
National Poisons Information Service (Birmingham Center), West Midlands Poisons Unit, Dudley Road Hospital, Birmingham, United Kingdom.
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MeSH Terms
Administration, Inhalation
Anoxia / chemically induced
Fatal Outcome
Methemoglobinemia / chemically induced*
Nitrites / administration & dosage,  poisoning*
Substance-Related Disorders
Reg. No./Substance:
0/Nitrites; 542-56-3/isobutyl nitrite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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