Document Detail


Fatal methanol intoxication with different survival times--morphological findings and postmortem methanol distribution.
MedLine Citation:
PMID:  18639399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three corresponding cases of fatal methanol intoxication with different survival times were investigated ante-mortem and postmortem. Ante-mortem serum methanol concentrations were determined during treatment in hospital for 4 days. Furthermore, postmortem distribution of methanol in various tissues and fluids was measured after autopsy. Morphological and toxicological findings are discussed based on the literature. The morphological findings correlated with the different survival times. The results of the toxicological analyses were partly in keeping with previously published data. Interestingly, very high methanol levels were determined in brain with very low concentrations in femoral venous blood. These results may have implications for postmortem toxicological analysis, brain death diagnosis and organ explanation for transplantation.
Authors:
H Andresen; H Schmoldt; J Matschke; F A Flachskampf; E E Turk
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Publication Detail:
Type:  Journal Article     Date:  2008-07-17
Journal Detail:
Title:  Forensic science international     Volume:  179     ISSN:  1872-6283     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-29     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  206-10     Citation Subset:  IM    
Affiliation:
Institute of Legal Medicine, University of Hamburg, Germany. h.andresen@uke.uni-hamburg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Bile / metabolism
Brain / metabolism
Chromatography, Gas
Forensic Toxicology
Humans
Kidney / metabolism
Liver / metabolism
Lung / metabolism
Male
Methanol / analysis,  pharmacokinetics*,  poisoning*
Postmortem Changes*
Solvents / analysis,  pharmacokinetics*,  poisoning*
Stomach / metabolism
Synovial Fluid / metabolism
Time Factors
Tissue Distribution
Vitreous Body / metabolism
Chemical
Reg. No./Substance:
0/Solvents; 67-56-1/Methanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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