Document Detail

Fatal intracranial hemorrhage in a newborn with factor VII deficiency.
MedLine Citation:
PMID:  8701495     Owner:  NLM     Status:  MEDLINE    
Factor VII deficiency is a rare congenital coagulopathy. Prolonged prothrombin time with normal partial thromboplastin time indicates factor VII deficiency. For the definitive diagnosis, the specific factor VII level should be investigated. We report a seven-day-old, male, full-term newborn who was admitted with the diagnosis of sepsis. Hematological tests revealed prolonged prothrombin time and a factor VII level of five percent. After antibiotic therapy and fresh frozen plasma replacement his clinical status improved but the prothrombin time continued to be prolonged. On the 14th day, just before the end of antibiotic therapy, the infant died of sudden intracerebral hemorrhage. In this article, the clinical features and management of factor VII deficiency are discussed.
R Uçsel; S Savaşan; A Coban; F Metin; G Can
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Turkish journal of pediatrics     Volume:  38     ISSN:  0041-4301     ISO Abbreviation:  Turk. J. Pediatr.     Publication Date:    1996 Apr-Jun
Date Detail:
Created Date:  1996-09-03     Completed Date:  1996-09-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417505     Medline TA:  Turk J Pediatr     Country:  TURKEY    
Other Details:
Languages:  eng     Pagination:  257-60     Citation Subset:  IM    
Department of Pediatrics, Istanbul University Faculty of Medicine.
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MeSH Terms
Cerebral Hemorrhage / diagnosis,  etiology*
Factor VII Deficiency / complications*,  congenital,  diagnosis
Fatal Outcome
Infant, Newborn
Sepsis / complications,  therapy

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