| Fatal infection in human flora-associated piglets caused by the opportunistic pathogen Klebsiella pneumoniae from an apparently healthy human donor. | |
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MedLine Citation:
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PMID: 18685245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seventeen out of 24 human flora-associated (HFA) piglets died after oral administration of whole fecal flora from an apparently healthy human donor. The bacteria isolated from the organs of the infected piglets were identified as Klebsiella pneumoniae by bacteriological and biochemical tests and 16S rRNA gene sequence analysis. The identical K. pneumoniae strain was also isolated from the donor's fecal flora. All three neonatal piglets inoculated with K. pneumoniae from the donor's fecal flora developed severe diarrhea, with 2 eventually dying. This strongly suggests that the opportunistic pathogen K. pneumoniae from the human donor caused the fatal infection in the HFA piglets. The results underscore the importance of safety evaluation of the human donor's fecal flora for HFA piglet development. |
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Authors:
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Hua Wei; Jian Shen; Xiaoyan Pang; Dezhong Ding; Yan Zhang; Baorang Zhang; Haifeng Lu; Tingting Wang; Chenhong Zhang; Xiuguo Hua; Li Cui; Liping Zhao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 70 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-08-07 Completed Date: 2008-10-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 715-7 Citation Subset: IM |
Affiliation:
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Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Bioscience and Biotechnology, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, P.R. China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Gastrointestinal Tract / microbiology* Humans Klebsiella Infections / microbiology, veterinary* Klebsiella pneumoniae / growth & development* Models, Animal Opportunistic Infections / microbiology, veterinary* Swine Swine Diseases / microbiology* |
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