Document Detail

Fatal hypothermia related vacuolation of hormone-producing cells in the anterior pituitary.
MedLine Citation:
PMID:  15231284     Owner:  NLM     Status:  MEDLINE    
We found small cytoplasmic vacuoles in the hormone-producing cells of anterior pituitary in hypothermic death. The vacuoles were found in approximately 40% of anterior pituitary cells both in males and females that had died from cold (n=31) while the detection rate was lower than 1% (P <0.001) in the other causes of death (n=180: fire death, n=25; fatal injury, n=24; asphyxia, n=24; poisoning, n=8; natural diseases, n=103). The detection rate in hypothermic death was the highest in ACTH cells (about 65%), followed by gonadotrophs (about 43%), and the lowest in TSH cells (about 16%) (P <0.001). These findings suggest that the cytoplasmic vacuoles in the anterior pituitary cells may be the most closely related to cold exposure among the above-mentioned cause of death, providing a supplementary evidence for determining the causes of death.
T Ishikawa; S Miyaishi; T Tachibana; H Ishizu; B-L Zhu; H Maeda
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Legal medicine (Tokyo, Japan)     Volume:  6     ISSN:  1344-6223     ISO Abbreviation:  Leg Med (Tokyo)     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-02     Completed Date:  2005-01-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100889186     Medline TA:  Leg Med (Tokyo)     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  157-63     Citation Subset:  IM    
Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8558, Japan.
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MeSH Terms
Adrenocorticotropic Hormone / metabolism
Asphyxia / mortality,  pathology
Cold Temperature
Hypothermia / mortality*,  pathology*
Microscopy, Electron
Middle Aged
Pituitary Gland, Anterior / metabolism,  pathology*,  ultrastructure
Pituitary Hormones, Anterior / metabolism*
Poisoning / mortality,  pathology
Thyrotropin / metabolism
Vacuoles / pathology*
Wounds and Injuries / mortality,  pathology
Reg. No./Substance:
0/Pituitary Hormones, Anterior; 9002-60-2/Adrenocorticotropic Hormone; 9002-71-5/Thyrotropin

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