Document Detail

Fatal hepatotoxicity after re-exposure to isoflurane: a case report and review of the literature.
MedLine Citation:
PMID:  10958225     Owner:  NLM     Status:  MEDLINE    
A 76-year-old Caucasian woman developed fulminant hepatic necrosis 6 days after an uneventful operation under isoflurane anaesthesia. Laboratory findings included elevated bilirubin, grossly elevated transaminases and prolonged prothrombin time. Radiological investigation showed no evidence of extra-hepatic disease. Serological studies were negative for acute viral hepatitis and autoimmune disease. The patient may have been previously sensitized by exposure to isoflurane 3 years previously but antibodies to tri-fluoro acetate, present in 70% of cases of halothane hepatitis, were not detected in pre-operative or postoperative samples of blood. On the seventh postoperative day the patient died and postmortem examination demonstrated centrilobular necrosis of the liver, with a histological pattern similar to changes associated with halothane hepatitis.
G B Turner; D O'Rourke; G O Scott; T R Beringer
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  12     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-21     Completed Date:  2000-12-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  955-9     Citation Subset:  IM    
Department of Health Care for the Elderly, Royal Victoria Hospital, Belfast, UK.
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MeSH Terms
Amputation / adverse effects,  methods
Anesthesia, General / adverse effects*,  methods
Anesthetics, Inhalation / administration & dosage,  adverse effects*
Drug-Induced Liver Injury*
Fatal Outcome
Isoflurane / administration & dosage,  adverse effects*
Liver / pathology
Liver Diseases / pathology
Postoperative Period
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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