Document Detail

Fatal group A streptococcal necrotizing fasciitis and toxic shock syndrome in a patient with psoriasis and chronic renal impairment.
MedLine Citation:
PMID:  12121397     Owner:  NLM     Status:  MEDLINE    
A 78-year-old woman presented with rapid onset of skin pain which evolved into oedema, discoloration and infarction. She was diagnosed with group A beta-haemolytic streptococcus (Streptococcus pyogenes) necrotizing fasciitis and streptococcal toxic shock syndrome. The patient had a past history of psoriasis and end-stage renal impairment. Despite treatment with multiple antibiotics in an intensive care unit, the skin infarction involving the upper trunk continued to expand and the patient died within 24 hours of hospital admission. Group A streptococcus and Staphylococcus aureus were cultured from a tissue biopsy. Renal failure and compromised skin barrier function are known to predispose to invasive streptococcal infections, but necrotizing fasciitis has only rarely been reported in association with psoriasis. This case illustrates the fulminant nature of the infection.
Alvin H Chong; Nigel P Burrows
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Australasian journal of dermatology     Volume:  43     ISSN:  0004-8380     ISO Abbreviation:  Australas. J. Dermatol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-17     Completed Date:  2002-09-17     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0135232     Medline TA:  Australas J Dermatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  194-8     Citation Subset:  IM    
Department of Dermatology, Addenbrooke's Hospital, Cambridge, United Kingdom.
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MeSH Terms
Anti-Bacterial Agents
Biopsy, Needle
Combined Modality Therapy
Debridement / methods
Disease Progression
Drug Therapy, Combination / administration & dosage
Fasciitis, Necrotizing / complications,  microbiology*,  pathology,  therapy
Fatal Outcome
Kidney Failure, Chronic / complications,  diagnosis*,  therapy
Psoriasis / complications,  diagnosis*,  therapy
Shock, Septic / complications,  diagnosis,  microbiology*,  therapy
Streptococcal Infections / complications,  diagnosis*,  therapy
Streptococcus pyogenes / isolation & purification*
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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