Document Detail

Fatal group B streptococcal pneumonia in neonates. Effects of antibiotics.
MedLine Citation:
PMID:  7032279     Owner:  NLM     Status:  MEDLINE    
Prophylactic penicillin has been suggested to prevent neonatal group B streptococcal infections (GBS). However, there is a concern that the antibiotics may conceal significant bacteremia if post-treatment blood cultures were used to recover the etiologic agent. To clarify this point, the autopsy records of 111 cases of fatal neonatal pneumonias is infants less than one week of age for the period 1974-1978 were reviewed. Nineteen documented cases of group B streptococcal infections were uncovered. Review of antibiotic therapy in these infants indicate that such therapy can indeed conceal the etiologic agent of pneumonia if one uses post treatment blood (or other normally sterile body fluids) cultures as the basis of diagnosis. On the other hand, review of 41 cases with morphologic evidence of pneumonia and no identifiable etiologic agent reveal that the majority of these were referral cases from outlying hospitals who received antibiotics prior to any diagnostic work-up.
A C Hamoudi; A B Hamoudi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  76     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  823-6     Citation Subset:  AIM; IM    
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Infant, Newborn
Infant, Newborn, Diseases / prevention & control*
Pneumonia / etiology,  prevention & control*
Streptococcal Infections / prevention & control*
Streptococcus agalactiae / isolation & purification
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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