| Fatal eosinophilic heart disease in a child with neurofibromatosis-1 complicated by acute lymphoblastic leukemia. | |
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MedLine Citation:
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PMID: 15912309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a pediatric case of neurofibromatosis-1 (NF-1) complicated by acute lymphoblastic leukemia and hypereosinophilia, which caused multiple end-organ damage. Although clinical symptoms such as fever and coughing were noted only 1 week before admission, the condition deteriorated rapidly with a fatal outcome prior to antileukemic therapy. A postmortem examination demonstrated extensive endomyocardial fibrosis with thrombotic occlusion and recanalization of the coronary arteries. Leukemic cell infiltration was not seen in the cardiac tissue. When eosinophilia is diagnosed in patients with NF-1, eosinophilic end-organ damage, particularly cardiac involvement, in addition to hematological malignancies, should be screened for in order to start medical treatment at the early stage of the disease. |
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Authors:
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Hitoshi Horigome; Ryo Sumazaki; Nobuaki Iwasaki; Natsuki Imoto; Hideyo Kinugasa; Makoto Saito; Akira Matsui |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Heart and vessels Volume: 20 ISSN: 0910-8327 ISO Abbreviation: Heart Vessels Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-24 Completed Date: 2005-12-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: Japan |
Other Details:
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Languages: eng Pagination: 120-2 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan. hhorigom@md.tsukuba.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Fatal Outcome Humans Hypereosinophilic Syndrome / complications* Male Neurofibromatosis 1 / complications* Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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