Document Detail

Fatal eosinophilic heart disease in a child with neurofibromatosis-1 complicated by acute lymphoblastic leukemia.
MedLine Citation:
PMID:  15912309     Owner:  NLM     Status:  MEDLINE    
We present a pediatric case of neurofibromatosis-1 (NF-1) complicated by acute lymphoblastic leukemia and hypereosinophilia, which caused multiple end-organ damage. Although clinical symptoms such as fever and coughing were noted only 1 week before admission, the condition deteriorated rapidly with a fatal outcome prior to antileukemic therapy. A postmortem examination demonstrated extensive endomyocardial fibrosis with thrombotic occlusion and recanalization of the coronary arteries. Leukemic cell infiltration was not seen in the cardiac tissue. When eosinophilia is diagnosed in patients with NF-1, eosinophilic end-organ damage, particularly cardiac involvement, in addition to hematological malignancies, should be screened for in order to start medical treatment at the early stage of the disease.
Hitoshi Horigome; Ryo Sumazaki; Nobuaki Iwasaki; Natsuki Imoto; Hideyo Kinugasa; Makoto Saito; Akira Matsui
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  20     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-24     Completed Date:  2005-12-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  120-2     Citation Subset:  IM    
Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
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MeSH Terms
Child, Preschool
Fatal Outcome
Hypereosinophilic Syndrome / complications*
Neurofibromatosis 1 / complications*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*

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