Document Detail

Fatal disseminated herpes simplex in pregnancy with maternal and neonatal death.
MedLine Citation:
PMID:  8685765     Owner:  NLM     Status:  MEDLINE    
Disseminated herpes is rare in the adult and usually occurs in the immunocompromised. Twenty-one cases have been reported in which healthy women contracted life-threatening disseminated herpes simplex virus (HSV) infections in the third trimester of pregnancy. Most of these patients had nonspecific symptoms, and many did not have mucocutaneous lesions. On physical examination, they were usually febrile and anicteric and had markedly elevated aminotransferase values, without a corresponding elevation in bilirubin level. In our review of the literature, we found that prompt acyclovir therapy resulted in 100% survival. Those patients not receiving treatment or treated late in the terminal stages of their disease had a 63% mortality rate. We report a case of maternal disseminated HSV with subsequent maternal death at an estimated 31 weeks' gestation in which the diagnosis was made at the time of necropsy. The infant was started on acyclovir therapy but died of disseminated HSV.
P L Gelven; K K Gruber; F K Swiger; S J Cina; R A Harley
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  89     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-20     Completed Date:  1996-08-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  732-4     Citation Subset:  AIM; IM    
Department of Pathology and Laboratory Medicine, Medical University of South Carolina , Charleston 29425, USA.
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MeSH Terms
Acyclovir / therapeutic use
Fatal Outcome
Herpes Simplex* / drug therapy
Infant, Newborn
Pregnancy Complications, Infectious* / drug therapy
Pregnancy Trimester, Third
Reg. No./Substance:

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