Document Detail

Fatal disseminated cryptococcosis and concurrent ehrlichiosis in a dog.
MedLine Citation:
PMID:  3508465     Owner:  NLM     Status:  MEDLINE    
Laboratory findings in an adult bull terrier presented with a history of anorexia and weight loss included the following: severe anaemia, leukocytosis, neutrophilia, lymphopaenia, thrombocytopaenia, Ehrlichia canis morulae in monocytes, hypergammaglo-bulinaemia, a bleeding tendency, icterus and proteinuria. In addition, a high Haemobartonella canis parasitaemia, non-encapsulated yeasts on urinalysis and a localised Demodex canis infestation were present. Treatment for ehrlichiosis was initiated but the dog died. Lesions found were a severe cryptococcal granulomatous pneumonia and cryptococcal colonies in the lungs, bronchial lymph nodes, kidneys, liver, spleen, heart, meninges, eyes and thoracic cavity. In addition, hyphal forms resembling Filobasidiella neoformans, the teleomorph of Cryptococcus neoformans, were seen in lung fine needle aspiration smears, impression smears and lung sections. C. neoformans was cultured from urine, lung and liver. Lung and kidney also yielded Salmonella typhimureum. Cortical atrophy with T-cell depletion of lymph nodes as well as splenic lymphoid follicular atrophy, typical of chronic ehrlichiosis-induced cell mediated immunosuppression, could have predisposed to the fatal disseminated cryptococcis.
M G Collett; A S Doyle; F Reyers; T Kruse; B Fabian
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the South African Veterinary Association     Volume:  58     ISSN:  1019-9128     ISO Abbreviation:  J S Afr Vet Assoc     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1989-06-14     Completed Date:  1989-06-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7503122     Medline TA:  J S Afr Vet Assoc     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  197-202     Citation Subset:  IM    
Department of Pathology, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Republic of South Africa.
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MeSH Terms
Anaplasmataceae / isolation & purification
Anaplasmataceae Infections / complications,  microbiology,  veterinary
Cryptococcosis / complications,  microbiology,  pathology,  veterinary*
Dog Diseases* / microbiology,  pathology
Ehrlichia / isolation & purification
Rickettsiaceae Infections / microbiology,  pathology,  veterinary*

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