Document Detail


Fatal cumulative toxicities of HAART in a stable, AIDS-free, HIV-infected patient.
MedLine Citation:
PMID:  22605589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors describe the case of fatal cumulative toxicities in a 58-year-old AIDS-free, HIV-infected patient, who successively developed under highly active antiretroviral therapy (HAART): severe lipodystrophy, complicated osteoporosis, complicated non-cirrhotic portal hypertension of the liver (with ascites, portal thrombosis, oesophageal varices and protein-losing enteropathy) due to nodular regenerative hyperplasia. These cumulative HAART-related toxicities led to death, despite symptomatic treatment and the switch of antiretrovirals (especially didanosine) putatively involved in the process in these drug-mediated diseases. As morbidity and mortality in HIV infection continue to improve, it appears important to recognise such rare HAART-associated toxicities. This case illustrates the absolute necessity of investigating the long-term side effects of HAART in HIV infection, particularly in patients treated with first generation molecules. The switch strategy (switching old molecules to newer ones) is crucial in case of severe suspected toxicity and has to be discussed in asymptomatic patients largely exposed to first generation molecules, in order to prevent long-term toxicity.
Authors:
Julien Saison; Laurent Cotte; Christian Chidiac; Tristan Ferry
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-03-08
Journal Detail:
Title:  BMJ case reports     Volume:  2012     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-18     Completed Date:  2013-02-12     Revised Date:  2014-03-12    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antiretroviral Therapy, Highly Active / adverse effects*
Fatal Outcome
HIV Infections / complications*,  drug therapy*
Humans
Hypertension, Portal / etiology
Lipodystrophy / etiology
Male
Middle Aged
Osteoporosis / etiology
Protein-Losing Enteropathies / etiology
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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