| Fatal community-associated methicillin-resistant Staphylococcus aureus pneumonia in an immunocompetent young adult. | |
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MedLine Citation:
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PMID: 16271665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Severe pneumonia caused by community-associated methicillin-resistant Staphylococcus aureus (MRSA) was reported in children soon after this pathogen emerged in the United States in the 1990s. Genes for Panton Valentine leukocidin, which are present in the majority of community-associated MRSA, are thought to enhance the ability of S aureus to cause necrotizing pneumonia. Despite the rapid spread throughout the United States of community-associated MRSA and related skin and soft-tissue infections, reports of severe pneumonia in adults have been rare. We describe a case of a healthy young adult who initially was treated as an outpatient with levofloxacin for what appeared to be typical community-acquired pneumonia. He soon returned to the emergency department (ED) with rapidly fatal necrotizing pneumonia, associated with hemoptysis, leukopenia, and sepsis syndrome, that was caused by community-associated MRSA carrying genes for Panton Valentine leukocidin. This case highlights the typical features of this form of pneumonia and the need to consider MRSA when evaluating and treating severe pneumonia in the ED. It also raises the question of whether the incidence of this form of pneumonia might be increasing in communities with a high prevalence of community-associated MRSA and whether current pneumonia treatment guidelines should be modified. |
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Authors:
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Bradley W Frazee; Toby O Salz; Larry Lambert; Francoise Perdreau-Remington |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2005-08-01 |
Journal Detail:
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Title: Annals of emergency medicine Volume: 46 ISSN: 1097-6760 ISO Abbreviation: Ann Emerg Med Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-07 Completed Date: 2006-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8002646 Medline TA: Ann Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 401-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Emergency Medicine, Alameda County Medical Center-Highland Campus, Oakland, CA 94602, USA. bfrazee@hghed.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Community-Acquired Infections / diagnosis, drug therapy, immunology, microbiology Diagnosis, Differential Fatal Outcome Humans Immunocompetence Male Methicillin Resistance* Pneumonia, Pneumococcal / diagnosis Pneumonia, Staphylococcal / diagnosis*, drug therapy*, immunology, microbiology Staphylococcus aureus / isolation & purification |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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