| Fatal case of tumor-associated hemorrhage in a large vestibular schwannoma. | |
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MedLine Citation:
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PMID: 20583739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vestibular schwannomas are benign neoplasms that arise from Schwann cells of the eighth cranial nerve. Most manifest clinically with tinnitus, unilateral sensorineural hearing loss, and dysequilibrium secondary to compression of the vestibulocochlear nerve; major adverse events such as intratumoral hemorrhage causing acute neurologic deterioration are rare. We report the case of a 69-year-old man with a large vestibular schwannoma who required anticoagulation for several medical comorbidities. The patient began having progressively worsening neurologic symptoms, including facial nerve paralysis and dysequilibrium, which confined him to a wheelchair. After presentation, the patient was admitted to the hospital. Several days after alteration of his anticoagulation therapy in preparation for surgery, he developed intracranial hemorrhage. Attempts were made to stabilize the patient, including posterior fossa craniectomy and evacuation of hematoma; however, the intracranial hemorrhage ultimately resulted in a fatal outcome. During this procedure, a biopsy specimen was obtained, showing benign vestibular schwannoma. The literature for intratumoral hemorrhage into vestibular schwannoma and the pathologic findings in our case are reviewed. |
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Authors:
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Charles W Yates; Mitchell Weinberg; Mark J Packer; Abraham Jacob |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Annals of otology, rhinology, and laryngology Volume: 119 ISSN: 0003-4894 ISO Abbreviation: Ann. Otol. Rhinol. Laryngol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0407300 Medline TA: Ann Otol Rhinol Laryngol Country: United States |
Other Details:
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Languages: eng Pagination: 402-5 Citation Subset: AIM; IM |
Affiliation:
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The Ohio State University, Dept of Otolaryngology-Head and Neck Surgery, OSU Eye and Ear Institute, 915 Olentangy River Rd, Columbus, OH 43212, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anticoagulants / therapeutic use Comorbidity Disease Progression Fatal Outcome Heart Valve Prosthesis Humans Immunohistochemistry Intracranial Hemorrhages / etiology* Magnetic Resonance Imaging Male Neuroma, Acoustic / complications*, epidemiology, metabolism Retrospective Studies Warfarin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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