| Fatal case of bilateral internal jugular vein thrombosis following IVIg infusion in an adolescent girl treated for ITP. | |
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MedLine Citation:
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PMID: 17975805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravenous immunoglobulin (IVIg) is often used as therapy in immune-mediated diseases and is generally considered a safe therapeutic agent. However, thrombotic complications such as myocardial infarction and deep vein thrombosis have been reported, although primarily in older adults. We describe a 13-year-old girl who received one dose of IVIg for immune thrombocytopenic purpura and developed fatal bilateral jugular venous thromboses. This is the first known case of IVIg-associated thrombosis in an adolescent and also the first report describing internal jugular vein thrombosis associated with IVIg infusion. We identify additional risks that may potentiate the agent's thrombotic risk. |
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Authors:
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Pui-Ying Iroh Tam; Matthew Richardson; SatKiran Grewal |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of hematology Volume: 83 ISSN: 1096-8652 ISO Abbreviation: Am. J. Hematol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-10 Completed Date: 2008-06-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 323-5 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley-Liss, Inc. |
Affiliation:
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Department of Pediatrics, Baystate Children's Hospital, Tufts University School of Medicine, 759 Chestnut St, Springfield, MA 01199, USA. pui-ying.irohtam@bhs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anemia, Iron-Deficiency / drug therapy, etiology Anticoagulants / therapeutic use Brain Edema / etiology* Combined Modality Therapy Dexamethasone / therapeutic use Ethinyl Estradiol / adverse effects, therapeutic use Fatal Outcome Female Heparin / therapeutic use Humans Immunoglobulins, Intravenous / adverse effects* Infusions, Intravenous Jugular Veins* Mannitol / therapeutic use Metrorrhagia / drug therapy, etiology Norethindrone / adverse effects, therapeutic use Obesity / complications Purpura, Thrombocytopenic, Idiopathic / complications, therapy* Thrombectomy Thrombolytic Therapy Venous Thrombosis / drug therapy, etiology*, surgery |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Immunoglobulins, Intravenous; 50-02-2/Dexamethasone; 57-63-6/Ethinyl Estradiol; 68-22-4/Norethindrone; 69-65-8/Mannitol; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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