Document Detail

Fatal association of mechanical valve thrombosis with dabigatran: a report of two cases.
MedLine Citation:
PMID:  23880682     Owner:  NLM     Status:  MEDLINE    
Several new oral anticoagulants have been approved for thromboembolism prevention in patients with nonvalvular atrial fibrillation. However, they are not yet approved for anticoagulation use in patients with prosthetic mechanical valves, and no randomized data have been published so far on their safety of use in these patients. We present two cases of patients with prosthetic mechanical mitral valves who were switched from warfarin and acenocoumarol to dabigatran and within 1 month experienced severe valve complications resulting in death. One patient experienced stroke and later cardiogenic shock and death, and the other experienced pulmonary edema, cardiogenic shock, and subsequent death.
Shaul Atar; Alice Wishniak; Alexander Shturman; Sewaed Shtiwi; Marc Brezins
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  144     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-24     Completed Date:  2013-09-30     Revised Date:  2013-12-09    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-8     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antithrombins / adverse effects,  therapeutic use
Atrial Fibrillation / surgery*
Benzimidazoles / adverse effects*,  therapeutic use*
Fatal Outcome
Heart Valve Prosthesis*
Mitral Valve*
Thromboembolism / prevention & control*
beta-Alanine / adverse effects,  analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Antithrombins; 0/Benzimidazoles; 11P2JDE17B/beta-Alanine; I0VM4M70GC/dabigatran

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A Case of Hut Lung: Scanning Electron Microscopy With Energy Dispersive X-ray Spectroscopy Analysis ...
Next Document:  Perioperative risk and management in patients with pulmonary hypertension.