| Fatal allopurinol-induced hypersensitivity syndrome associated with pancreatic abnormalities. | |
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MedLine Citation:
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PMID: 20511977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Allopurinol hypersensitivity syndrome is a severe adverse reaction characterized by rash, fever, and internal organ involvement. We report a case of fatal allopurinol-induced hypersensitivity syndrome associated with acute pancreatitis.A 46-year-old man was treated by allopurinol for asymptomatic hyperuricemia. The patient developed a diffuse erythrodermic maculopapular eruption and fever. Laboratory analysis revealed cytolysis and cholestasis, amylases and lipases were highly elevated. Computed tomography scans revealed pancreatitis Grade C. The treatment of asymptomatic hyperuricemia should only be initiated when there is a clear indication to reduce the incidence and the severe consequences of allopurinol hypersensitivity syndrome. |
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Authors:
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Neila Fathallah; Chaker Ben Salem; Raoudha Slim; Naoufel Kaabia; Amel Letaief; Kamel Bouraoui |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases Volume: 16 ISSN: 1536-7355 ISO Abbreviation: J Clin Rheumatol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9518034 Medline TA: J Clin Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 170-1 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Sousse, Tunisia. neilafathallah@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Allopurinol
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adverse effects* Drug Eruptions / complications, etiology* Fatal Outcome Gout Suppressants / adverse effects* Humans Hyperuricemia / drug therapy* Male Middle Aged Pancreatitis / chemically induced*, complications |
| Chemical | |
Reg. No./Substance:
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0/Gout Suppressants; 315-30-0/Allopurinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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